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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Am J Med Genet A. 2010 Sep;152A(9):2268–2276. doi: 10.1002/ajmg.a.33579

Figure 4.

Figure 4

Comparison of an age-matched control (right) with Twin A at 2.5 months (left). Fractional Anisotropy (FA) axial map of Twin A (Figure A) and coronal tractography (Figure C) outline attenuated corticospinal tracts and absent transverse fibers. FA of the age-matched control (Figure B) shows normal pontocerebellar transverse fibers traveling in X- axis depicted in red color. Coronal tractography map of a normal control (Figure D) outlines normal corticospinal fibers in blue and transverse fibers in red. Note the absent transverse pontine fibers with an axon stain in brainstem neuropathology from a 15-year-old patient with PCH2 (E), compared with normal transverse pontine fibers from an 8-year-old normal control (figures courtesy of Professor Peter G. Barth, Department of Neuropathology, Academic Medical Centre, University of Amsterdam. The Netherlands).