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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2010 Jun 22;9(7):1977–1984. doi: 10.1158/1535-7163.MCT-10-0141

Figure 2.

Figure 2

TSA enhances caspase activation induced by PS-341 in HNSCC cells. A, TSA enhanced caspase activation induced by PS-341 in UMSCC1 cells. UMSCC-1 cells were treated with PS-341 alone, TSA alone, or PS-341 and TSA together for 0, 4, 8, 12, or 16 h. Whole cell extracts were prepared, and 50- µg aliquots of proteins were probed with anti-caspase-3, anti-caspase-7, and anti-caspase-9 antibodies. For the loading control, the membrane was stripped and re-probed with monoclonal antibodies against α-tubulin. B, TSA enhanced caspase activation induced by PS-341 in UMSCC23 cells. P+T, PS-341 + TSA.