Paracrine FGF10 promoted androgen independent survival of a subset of prostate adenocarcinoma
A: Histology of the FGF10 and WT mesenchyme regenerated grafts harvested from castrated animals. Contrary to normal WT regenerated grafts, persistence of adenocarcinoma was noted in all five FGF10 regenerated specimens.
B: Immunohistochemical localization of AR in FGF10 grafts obtained from intact and castrated animals. Castration led to partial cytoplasmic transport of AR in castrate (c&d) compared to intact grafts (a&b). Partial nuclear localization of AR persisted despite castration in the FGF10 regenerated tissue (c&d).
C: Comparative analysis of weight (mean±SD) of grafts harvested from intact and castrate animals.