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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Cancer Cell. 2007 Dec;12(6):572–585. doi: 10.1016/j.ccr.2007.11.002

Figure 5.

Figure 5

Paracrine FGF10 promoted androgen independent survival of a subset of prostate adenocarcinoma

A: Histology of the FGF10 and WT mesenchyme regenerated grafts harvested from castrated animals. Contrary to normal WT regenerated grafts, persistence of adenocarcinoma was noted in all five FGF10 regenerated specimens.

B: Immunohistochemical localization of AR in FGF10 grafts obtained from intact and castrated animals. Castration led to partial cytoplasmic transport of AR in castrate (c&d) compared to intact grafts (a&b). Partial nuclear localization of AR persisted despite castration in the FGF10 regenerated tissue (c&d).

C: Comparative analysis of weight (mean±SD) of grafts harvested from intact and castrate animals.