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. 2010 Aug 20;11:18. doi: 10.1186/1471-2369-11-18

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Copyright ©2010 Langheinrich et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Quantitative 3D micro-CT imaging. Micro-CT imaging (maximum intensity projection, A, B, G, H; single-slice, E, F) of controls (A, C, E, G) and apoE^-/-/LDL^-/-double knockout mice (B, D, F, H). Reduced intrarenal vascular volume is present in apoE^-/-/LDL^-/-double knockout mice at the age of 80 weeks (B, D) compared to controls (A, C). Volume-rendering from controls (C) and double-knockout mice (D) demonstrate the reduced vascular perfusion territories of the intra-renal arterial (red) and venous (blue) vasculature. Nano-CT imaging demonstrates irregular vascular branching with luminal enchroachments in apoE^-/-/LDL^-/-double knockout mice (F) compared to controls (E).