Table 1.
Quantitative micro-CT measurements
| C57/BL mouse (Controls) | ApoE-/-/LDL-/- double knockout mouse | |
|---|---|---|
| Total Vascular Volume Fraction (mm3) | 4.3 ± 0.4 | 3.2 ± 0.3* |
| Venous Vascular Volume Fraction (mm3) | 3.9 ± 0.3 | 2.9 ± 0.4* |
| Arterial Vascular Volume Fraction (mm3) | 0.4 ± 0.1 | 0.3 ± 0.1 |
| Maximum Kidney Dimension (mm) | 10.6 ± 1.7 | 11.5 ± 1.9 |
| Number of Glomeruli (per cross-section) | 17 ± 3 | 24 ± 5* |
| Number of Diseased Glomeruli (per cross-section | 0 | 11 ± 3* |
| Glomeruli cross-sectional surface area (μm2) | 3533 ± 358 | 9959 ± 658* |
| Diameter Glomerular Capillaries (μm) | 8.2 ± 2.3 | 22.3 ± 3.9* |
A significant decrease in the total vascular volume fraction and a significant increase in the total number and area of glomeruli is present in apoE-/-/LDL-/- double knockout mice compared to controls (*p < 0.001). The decrease of the total vascular volume fraction is due to the decrease in the venous vascular volume fraction (p < 0.01). No significant difference in the arterial vascular volume fraction was found between the groups (p < 0.4).