. 2010 Aug 17;10:436. doi: 10.1186/1471-2407-10-436

Table 4.

Risk ratios for toxicity results

	IV topotecan vs CAV¹	IV vs Oral topotecan²	Oral topotecan vs CAV³
Grade 4 neutropenia	0.98 (0.82 to 1.17)	1.47 (1.22 to 1.78)	0.67 (0.51 to 0.87)

Grade 4 thrombocytopenia	5.83 (2.35, 14.42)	0.70 (0.49 to 1.01)	8.41 (3.17 to 22.35)

Grade 4 anaemia	1.46 (0.25 to 8.54)	0.60 (0.22 to 1.65)	2.46 (0.33 to 18.53)

1- Direct comparison (Von Pawel 1999); 2- Direct comparison (Von Pawel 2001 & Eckardt 2007); 3- Indirect comparison (Von Pawel 1999/Von Pawel 2001 & Eckardt 2007).