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. 2010 Jan 25;160(3):574–584. doi: 10.1111/j.1476-5381.2009.00579.x

Figure 5.

Figure 5

Influence of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol (CP 55,940) (1 µmol·kg−1) on the electrically stimulated increase in heart rate (HR) in pithed rats anaesthetized with pentobarbitone and its interaction with N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251) (3 µmol·kg−1), cannabidiol (CBD, 3 µmol·kg−1) and 1,3-dimethoxy-5-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-benzene (O-1918) (3 µmol·kg−1). An increase in HR was induced twice (S1 and S2, 10 min apart) by electrical stimulation (1 Hz, 1 ms, 50 V for 10 s) of the preganglionic sympathetic nerves. AM 251, CBD or O-1918 were administered 5 min before S1. CP 55,940 was injected 5 min before S2. To quantify the effects of CP 55,940, the ratio of S2/S1 was determined. S2/S1 values are expressed as percentages of the corresponding ratios in controls. All drugs were administered i.v. Mean ± SEM of 4–10 rats. **P < 0.01, ***P < 0.001 compared with the respective control (not shown). ΔΔP < 0.001 compared with the group without antagonist.