Table 2.

Effects of cannabinoid receptor antagonists, O-1918 and pertussis toxin, on relaxation to NAGly in small mesenteric arteries precontracted with methoxamine

With endothelium	pEC50%	Relaxation at 30 µM (%)	n
Control	5.7 ± 0.2	98 ± 1	5
+AM251 + JTE907	5.5 ± 0.2	93 ± 2	6
Control	5.3 ± 0.2	85 ± 5	6
+O-1918	–	38 ± 17	6**
Control	5.5 ± 0.2	91 ± 3	5
+Pertussis toxin	5.2 ± 0.2	87 ± 4	5*

Without endothelium	pEC20%	Relaxation at 30 µM (%)	n
Control	5.0 ± 0.1	63 ± 11	4
+O-1918	–	54 ± 18	4**
Control	5.3 ± 0.1	83 ± 7	5
+Pertussis toxin	5.4 ± 0.1	89 ± 3	5

Data are expressed as mean ± SEM. Where appropriate, pEC_50% and pEC_20% values were obtained directly from individual log concentration–response curves; n represents the number of animals.

^*P < 0.05,

^**P < 0.01 indicate significant difference from control values (two-way anova of the whole data set).