Figure 2.
Representative traces of the inhibition of the electrical field stimulation (0.1 Hz frequency, 0.5 ms duration and 110% supramaximal voltage)-evoked contractions of the guinea-pig myenteric plexus-longitudinal muscle by WIN 55,212-2 [(R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate] in the presence of (A) ethanol and (B) rimonabant (N-(piperidino)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxyamide) (10−6 M). WIN 55,212-2 was added in half-logarithmic unit increments. Lines represent intermediate concentrations.