Table 2.
Effects of (-)-cannabidiol (CBD) (5, 10, 15 and 20 mg·kg−1 i.p.) on the amplitude (ALF) and duration (D) of low-frequency spontaneous contractions
| Control | Vehicle | CBD5 | CBD10 | CBD15 | CBD20 | |
|---|---|---|---|---|---|---|
| ALF (g·g−1) | 195 ± 19 | 37 ± 5 | 41 ± 13 | 67 ± 11* | 47 ± 8 | 55 ± 10 |
| D (s) | 26.9 ± 1.7 | 62.8 ± 4.5 | 57.0 ± 7.8 | 46.2 ± 6.5* | 52.6 ± 2.8 | 38.7 ± 2.8* |
Longitudinal muscle strips from rat colon 3 days after administration of 2,4,6-trinitrobenzene sulphonic acid enema.
Control values (preliminary experiments, phosphate-buffered saline enema, no treatment) are shown. Contractions expressed in grams per gram of dry tissue weight. Results are expressed as mean ± SEM; n = 4–11.
*
P < 0.05 compared with the vehicle (ethanol : cremophor : saline, 1:1:18).