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Luciferase knockdown at low doses of siRNA. HeLa cells stably expressing firefly and Renilla luciferase were transfected using selected lipidoids at 15:1 lipidoid/siRNA ratio (wt/wt) at 0.5, 2.5, 5, 15 and 50 ng siRNA. Luminescence was measured after 24 hour incubation, and the results presented relative to an untransfected control set of cells. Lipidoids were purified isolate the n-1 isomer prior to transfection.
