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. Author manuscript; available in PMC: 2011 Aug 18.

Published in final edited form as: Bioconjug Chem. 2010 Aug 18;21(8):1448–1454. doi: 10.1021/bc100041r

In Vivo Silencing of Factor VII in Mice. Lipidoids shown to be efficacious in in vitro studies were formulated for intravenous delivery of anti-Factor VII siRNA to hepatocytes via tail vein injection. a) Mice were administered a single dose of 2.5 mg/kg siRNA and blood samples were drawn at 72 hours for detection of Factor VII levels in serum. b) Selected lipidoids are formulated with varied weight ratios of lipiods to siRNA and injected at doses of 4 and/ or 2mg/kg. Factor VII levels in all treated groups are expressed relative to PBS injected mice.

In Vivo Silencing of Factor VII in Mice. Lipidoids shown to be efficacious in in vitro studies were formulated for intravenous delivery of anti-Factor VII siRNA to hepatocytes via tail vein injection. a) Mice were administered a single dose of 2.5 mg/kg siRNA and blood samples were drawn at 72 hours for detection of Factor VII levels in serum. b) Selected lipidoids are formulated with varied weight ratios of lipiods to siRNA and injected at doses of 4 and/ or 2mg/kg. Factor VII levels in all treated groups are expressed relative to PBS injected mice.