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. 1959 Feb;38(2):366–372. doi: 10.1172/JCI103810

THE EFFECT OF THE ADMINISTRATION OF SODIUM BICARBONATE AND AMMONIUM CHLORIDE ON THE EXCRETION AND PRODUCTION OF AMMONIA. THE ABSENCE OF ALTERATIONS IN THE ACTIVITY OF RENAL AMMONIA-PRODUCING ENZYMES IN THE DOG

Floyd C Rector Jr 1, Jack Orloff 1
PMCID: PMC293164  PMID: 13631068

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CLARKE E., EVANS B. M., MACINTYRE I., MILNE M. D. Acidosis in experimental electrolyte depletion. Clin Sci. 1955 Aug;14(3):421–440. [PubMed] [Google Scholar]
  2. COUNIHAN T. B., EVANS B. M., MILNE M. D. Observations on the pharmacology of the carbonic anhydrase inhibitor diamox. Clin Sci. 1954 Nov;13(4):583–598. [PubMed] [Google Scholar]
  3. DAVIES B. M. A., YUDKIN J. Studies in biochemical adaptation; the origin or urinary ammonia as indicated by the effect of chronic acidosis and alkalosis on some renal enzymes in the rat. Biochem J. 1952 Nov;52(3):407–412. doi: 10.1042/bj0520407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DEARBORN E. H., GOLDSTEIN L., RICHTERICH-VAN BAERLE R. Increased activity of renal glutaminases in guinea pig following prolonged administration of acid or alkali. Proc Soc Exp Biol Med. 1956 Nov;93(2):284–287. doi: 10.3181/00379727-93-22733. [DOI] [PubMed] [Google Scholar]
  5. FERGUSON E. B., Jr A study of the regulation of the rate of urinary ammonia excretion in the rat. J Physiol. 1951 Feb;112(3-4):420–425. doi: 10.1113/jphysiol.1951.sp004539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GOLDSTEIN L., RICHTERICH-VANBAERLE R., DEARBORN E. H. Kidney glutaminases. II. The glutamine-alpha-keto acid transamination-deamidation system of the guinea pig. Enzymologia. 1957 Jun 15;18(4):261–270. [PubMed] [Google Scholar]
  7. IACOBELLIS M., MUNTWYLER E., GRIFFIN G. E. Enzyme concentration changes in the kidneys of protein- and/or potassium-deficient rats. Am J Physiol. 1954 Sep;178(3):477–482. doi: 10.1152/ajplegacy.1954.178.3.477. [DOI] [PubMed] [Google Scholar]
  8. IACOBELLIS M., MUNTWYLER E., GRIFFIN G. E. Kidney glutaminase and carbonic anhydrase activity and tissue electrolyte composition in potassium-deficient dogs. Am J Physiol. 1955 Dec;183(3):395–400. doi: 10.1152/ajplegacy.1955.183.3.395. [DOI] [PubMed] [Google Scholar]
  9. KAMIN H., HANDLER P. The metabolism of parenterally administered amino acids. III. Ammonia formation. J Biol Chem. 1951 Dec;193(2):873–880. [PubMed] [Google Scholar]
  10. Krebs H. A. Metabolism of amino-acids: The synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues. Biochem J. 1935 Aug;29(8):1951–1969. doi: 10.1042/bj0291951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LEONARD E., ORLOFF J. Regulation of ammonia excretion in the rat. Am J Physiol. 1955 Jul;182(1):131–138. doi: 10.1152/ajplegacy.1955.182.1.131. [DOI] [PubMed] [Google Scholar]
  12. MAREN T. H., WADSWORTH B. C., YALE E. K., ALONSO L. G. Carbonic anhydrase inhibition. III. Effects of diamox on electrolyte metabolism. Bull Johns Hopkins Hosp. 1954 Dec;95(6):277–321. [PubMed] [Google Scholar]
  13. MILNE M. D., SCRIBNER B. H., CRAWFORD M. A. Non-ionic diffusion and the excretion of weak acids and bases. Am J Med. 1958 May;24(5):709–729. doi: 10.1016/0002-9343(58)90376-0. [DOI] [PubMed] [Google Scholar]
  14. OLSON J. A., ANFINSEN C. B. The crystallization and characterization of L-glutamic acid dehydrogenase. J Biol Chem. 1952 May;197(1):67–79. [PubMed] [Google Scholar]
  15. ORLOFF J., BERLINER R. W. The mechanism of the excretion of ammonia in the dog. J Clin Invest. 1956 Feb;35(2):223–235. doi: 10.1172/JCI103267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. ORLOFF J. The rôle of the kidney in the regulation of acid-balance. Yale J Biol Med. 1956 Dec;29(3):211–228. [PMC free article] [PubMed] [Google Scholar]
  17. RECTOR F. C., Jr, SELDIN D. W., COPENHAVER J. H. The mechanism of ammonia excretion during ammonium chloride acidosis. J Clin Invest. 1955 Jan;34(1):20–26. doi: 10.1172/JCI103058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. RECTOR F. C., Jr, SELDIN D. W., ROBERTS A. D., Jr, COPENHAVER J. H. Relation of ammonia excretion to urine pH. Am J Physiol. 1954 Nov;179(2):353–358. doi: 10.1152/ajplegacy.1954.179.2.353. [DOI] [PubMed] [Google Scholar]
  19. REINER J. M., HUDSON P. B. Effect of age upon glutamine synthesis and glutamine amide exchange of rat liver, kidney and testis. J Urol. 1953 Oct;70(4):627–636. doi: 10.1016/S0022-5347(17)67963-1. [DOI] [PubMed] [Google Scholar]
  20. RICHTERICH-VAN BAERLE R., GOLDSTEIN L., DEARBORN E. H. Kidney glutaminases. III. Glutamine synthesis in the guinea pig kidney. Enzymologia. 1957 Jul 31;18(5):327–336. [PubMed] [Google Scholar]
  21. RICHTERICH-VAN BAERLE R., GOLDSTEIN L. Renal ammonia production as a model for the study of enzyme adaptation in mammals. Experientia. 1957 Jan 15;13(1):30–32. doi: 10.1007/BF02156949. [DOI] [PubMed] [Google Scholar]
  22. SELIGSON D., SELIGSON H. A microdiffusion method for the determination of nitrogen liberated as ammonia. J Lab Clin Med. 1951 Aug;38(2):324–330. [PubMed] [Google Scholar]
  23. Sartorius O. W., Roemmelt J. C., Pitts R. F., Calhoon D., Miner P. THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. IV. THE NATURE OF THE RENAL COMPENSATIONS IN AMMONIUM CHLORIDE ACIDOSIS. J Clin Invest. 1949 May;28(3):423–439. doi: 10.1172/JCI102087. [DOI] [PMC free article] [PubMed] [Google Scholar]

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