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. 2010 Sep 1;5(9):e12515. doi: 10.1371/journal.pone.0012515

Figure 4. Lodamin injected intravitreal suppresses CNV progression.

Figure 4

(A) CNV lesions were induced by a diode pumped solid state laser around the optic nerve through a slit lamp delivery system. Only lesions in which a subretinal bubble or focal serous detachment of the retina developed were used for the experiments. Four burns were performed per eye while leaving a space around the optic disc. At the day of laser induction intravitreal injection of Lodamin was performed. Size of CNV lesions after intravitreal injections of Lodamin: 100 µg Lodamin per eye (12.5 µg TNP-470 equivalent) or 300 µg Lodamin per eye. Data is presented as mean pixel number ± SEM (n = 7–17, *P<0.05, U-test). (B) Representative images of retinal flat-mounts stained with a lectin-FITC, Bars = 10 µm.