Figure 5. Comparison of the effect of Lodamin or sFlk-1 on choroidal vessel regression.

For CNV regression studies intravitreal injections of Lodamin or sFlk-1, a recombinant mouse VEGF R2/KDR Flk-1 Fc Chimera, were performed on established CNV lesions at day 7 post laser induction. After 14 days of laser induction (7 days post intravitreal injection of Lodamin or sFlk-1) fluorescent images of choroidal flat-mounts were captured and CNV area (presented in µm²) in choroidal flat mount was evaluated using Scion image software. (A) CNV size data of untreated mice bearing laser induced CNV at day 7 and 14, compared to Lodamin or sFlk-1 treated mice 7 days after their injection. Data is presented as mean pixel number ± SEM (n = 15–27 spots, *P<0.05, U-test).