Figure 6.
Structures of nonproductive salt bridges (shown in sticks) in several unsuccessful quench simulations. (a) Glu37-Arg29 and Arg30-Glu19-Arg15 salt bridges inhibited the native Arg30-Glu19 contacts from forming, and caused HI and HII to skew relative to each other. (b) The Glu22-Arg3 salt bridge is an example of several salt bridges that formed between the N-terminus and Glu22 and kept HI from fully forming. (c) Lys17 coordinated the backbone carbonyl groups of Phe8, Ser9, and Gln12, which stabilized the N-terminus in a nonnative orientation. (d) Lys52 formed a salt bridge with the C-terminus, kinking the end of HIII.