Table 1.
Number of contiguous myocytes with an EAD or DAD required to trigger a PVC in 1D, 2D, or 3D tissue
| EADs | ||||||||
|---|---|---|---|---|---|---|---|---|
| EAD/Normal Ggap = 780 nS | EAD/Normal GGap = 125 nS | EAD/Normal + Fibrosis GGap = 780 nS | EAD/Normal + Fibrosis Ggap = 125 nS | EAD/RRR Ggap = 780 nS | EAD/RRR Ggap = 125 nS | EAD/RRR + Fibrosis Ggap = 780 nS | EAD/RRR + Fibrosis Ggap = 125 nS | |
| 1D (cable) | 70 (10.5 mm) | 30 (4.5 mm) | — | — | 46 (6.9 mm) | 20 (3.0 mm) | - | - |
| 2D (ellipse) | 6940 (d = 14.1) | 1135 (d = 5.7) | 1,668 (d = 7.8) | 268 (d = 3.0) | 3217 (d = 9.6) | 531 (d = 3.9) | 504 (d = 4.2) | 112 (d = 1.8) |
| 3D (ellipsoid) | 696,910 (d = 16.5) | 50,965 (d = 6.9) | — | — | 229,850 (d = 11.4) | 17,157 (d = 4.8) | - | - |
| DADs | ||||||||
| DAD/Normal Ggap = 780 nS | DAD/Normal Ggap = 125 nS | DAD/Normal + Fibrosis Ggap = 780 nS | DAD/Normal + Fibrosis Ggap = 125 nS | DAD/HF Ggap = 780 nS | DAD/HF Ggap = 125 nS | DAD/HF +Fibrosis Ggap = 780 nS | DAD/HF + Fibrosis Ggap = 125 nS | |
| 1D (cable) | 80 (d = 12) | 32 (d = 4.8) | — | — | 22 (d = 3.3) | 10 (d = 1.5) | - | - |
| 2D (ellipse) | 7854 (d = 15) | 1256 (d = 6.3) | 1668 (d = 7.8) | 316 (d = 3.3) | 1018 (d = 5.4) | 202 (d = 2.4) | 136 (d = 1.5) | 40 (d = 0.9) |
| 3D (ellipsoid) | 817,280 (d = 17.4) | 57,906 (d = 7.2) | — | — | 50,965 (d = 6.9) | 4,189 (d = 3.0) | - | - |
EAD/Normal refers to a central region of cells that exhibit EADs surrounded by normal cells without EADs. The case is similar for the other labels, where the surrounding tissue was either normal or exhibited reduced repolarization reserve, heart failure changes (HF), or fibrosis. Gap junction conductance (Ggap) is also indicated for each case. Numbers in parentheses refer to the size (d) of the central region (in millimeters along the major axis) with cells that exhibit EADs or DADs.