Table 5.
Mean ± SD pharmacokinetic parameters for plasma FU
FU maintenance dose (mg/m2) | Vorinostat (mg) | Css (µg/mL) | Cmax (µg/mL) | AUC (µg h/mL) |
---|---|---|---|---|
2,400 | 600 twice daily | 0.271 ± 0.014 | 13.0 ± 3.17 | 24.8 ± 3.51 |
2,400 | — | 0.347 ± 0.092 | 11.2 ± 5.55 | 21.8 ± 9.68 |
2,400 | 1,700 once daily | 0.398 ± 0.106 | 14.2 ± 2.87 | 27.2 ± 5.11 |
2,400 | — | 0.439 ± 0.172 | 17.3 ± 2.97 | 29.9 ± 6.66 |
NOTE: Data were compared by paired Student's t-test. The difference in Cmax pre- and post-vorinostat on the 1,700 once-daily dose level was the only statistically significant finding (P < 0.05).