Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Vorinostat pharmacokinetics
| Patients | Cmax (µmol/L) | Tmax (h) | T1/2 (h) | AUC0–8 (µmol/L × h) | |
|---|---|---|---|---|---|
| 600 mg orally twice daily | 1 | 4.99 | 2 | 1.5 | 14.3 |
| 2 | 3.43 | 1 | 2.2 | 7.8 | |
| 3 | 1.97 | 4 | 2.3 | 10.2 | |
| Mean | 3.46 | 2.3 | 2.0 | 10.8 | |
| SD | 1.51 | 1.5 | 0.4 | 3.3 | |
| 1,700 mg orally once daily | 1 | 0.92 | 0.5 | 27.7 | 2.6 |
| 2 | 6.15 | 1 | 2.4 | 26 | |
| 3 | 6.40 | 4 | 3.2 | 35.1 | |
| Mean | 4.49 | 1.8 | 11.1 | 21.2 | |
| SD | 3.09 | 1.9 | 14.4 | 16.8 |
Note: T1/2, half-life
