. Author manuscript; available in PMC: 2010 Sep 2.

Published in final edited form as: Physiology (Bethesda). 2009 Jun;24:171–185. doi: 10.1152/physiol.00002.2009

Table 2.

GABA and tumors

Region	Type of Cancer	GABA Components	↑ Upregulated ↓ Downregulated	Effect on Proliferation
Brain	Neurocytoma	GABA (159), R_A (150)	↑ GABA (in 1/4)	ND
	Glioblastoma	GABA (AR) (87)	↓	ND
	Glioma	R_A (Patch) (95)	↑ In cells lines in contact with neurons (160)	Inhibition (160)
Liver	Human hepatocellular carcinoma	R_A (IHC)	↓ β3-subunit (118) ↑ α3-subunit (101)	Inhibition (β3) (118) Stimulation (α3) (101)
Pancreas	Pancreatic adenocarcinomas	R_A (RT-PCR) (86)	↑ π-subunit (162)	Stimulation (162)
	Human insulinoma (β-cell)	R_A (Patch) (66)	↑	ND
Prostate	Neuroendocrine cancer	GABA, R_A	↑ (1, 82)	Stimulation (82)