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Edotecarin/5-FU/LV treatment regimen
| Drug | Starting dose and route | Dosing schedule | |
|---|---|---|---|
| Edotecarin | X mg/m2 IV over 1 h | Day 1 | Every 2 weeks |
| LV | 200 mg/m2 IV over 2 h | Day 1 | Every 2 weeks |
| 5-FU | 2400 mg/m2 IV over 46 h | Day 1–2 | Every 2 weeks |
5-FU, 5-fluorouracil; IV, intravenous; LV, leucovorin.
X Edotecarin dose level was determined from Table 3 and was assigned by the sponsor when a patient was registered for the study.
