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Dose modification levels
| Edotecarin (mg/m2) | 5-FU (mg/m2)a 46-h infusion |
|
|---|---|---|
| 17 | Adjustment of edotecarin and 5-FU was made independently based on the specific types of toxicities that were observed | 3000a |
| 15 | 2400 | |
| 13 | 2000 | |
| 11 | 1600 | |
| 8 | ||
| 6 |
5-FU, 5-fluorouracil.
In cycle 3 and beyond, the infusional dose of 5-FU could have been increased to 3000 mg/m2 providing that there were no toxicities ≥grade 1 in the preceding cycle.
