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. Author manuscript; available in PMC: 2011 Nov 2.
Published in final edited form as: J Pharm Biomed Anal. 2010 Jun 9;53(3):777–780. doi: 10.1016/j.jpba.2010.05.016

Table 2.

Calculated binding affinities (Kd values) of the ERRγ antagonists, 4-hydroxytamoxifen, endoxifen and tamoxifen determined using non-linear chromatographic techniques on the ERRγ column and the corresponding dose-dependent effect on cellular proliferation (IC50 values) determined using a 48 hour MTS proliferation assay carried out using the human-derived T98G glioma cell line.

Kd values
ERRγ Column		 IC50 values
T98G cell line
4-Hydroxytamoxifen 16.3 nM 14.5 uM
Endoxifen 43.2 nM 3.4 uM
Tamoxifen 1510 nM 118 uM.