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. Author manuscript; available in PMC: 2010 Sep 2.
Published in final edited form as: Proc IEEE Inst Electr Electron Eng. 2001 Jul 1;89(7):1107–1122. doi: 10.1109/5.939827
X n by υ row mean-zero data matrix with n the
number of time points in the experiment;
υ total number of voxels in all slices;
G specified n by p design matrix containing the time
courses of all p factors hypothesized to modulate
the BOLD signal, including the behavioral manip-
ulations of the fMRI experiment;
β P by υ matrix of parameters to be estimated;
ε matrix of noise or residual errors typically assumed
to be independent, zero-mean and Gaussian dis-
tributed, i.e., N(0, σ2).