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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nat Struct Mol Biol. 2010 May 9;17(6):753–760. doi: 10.1038/nsmb.1816

Figure 6.

Figure 6

Model outlining how p53AD appears to trigger pol II promoter escape and transcription elongation. Top: Despite full PEC assembly, promoter-proximally stalled pol II remains unable to transition to a productively elongating state in the absence of the p53AD-directed structural shift within Mediator. Bottom: Mediator structural shifts, orchestrated by p53AD, activate stalled pol II to transition to a productively-elongating state. This Mediator-dependent activation appears to be triggered by formation of the pocket domain within Mediator, which interfaces extensively with pol II. Note the location and path of the pol II CTD within the PEC has not been clearly defined.