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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nat Struct Mol Biol. 2010 May 9;17(6):753–760. doi: 10.1038/nsmb.1816

Figure 7.

Figure 7

The pocket domain represents a common structural feature within activator-bound Mediator. Shown are “bottom” views of Mediator complexes bound to different activation domains. The location of the pocket is noted by the arrows. Mediator structures labeled “active” have been shown to activate transcription in a reconstituted system. Note that transcriptionally inactive structures (unliganded Mediator or p53CTD–Mediator structure) lack the pocket domain. The unliganded Mediator structure is not bound to an activator18. Studies with both yeast4 and human Mediator (Supplementary Fig. 14c) reveal that the pocket domain represents the pol II binding site within Mediator. For reference, the structure of the yeast pol II enzyme (pdb 1y1v) is also shown to the same relative scale.