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. Author manuscript; available in PMC: 2010 Sep 2.
Published in final edited form as: Mol Endocrinol. 2005 Jun 16;19(10):2610–2623. doi: 10.1210/me.2005-0047

Fig. 5.

Fig. 5

The SBE Sites Are Crucial to the LHβ Response to Activin

A, Rat LHβ promoter sequence from −121 to −86 bp from the start site of transcription is shown. In addition to the indicated homeobox and Egr sites, SBEs (S1, S2 and S3 numbering from 5′ to 3′) are circled for clear observation. B, Point mutations (2 bp) in each of the SBEs were separately introduced into the reporter (mS1, mS2, and mS3), and their induction by activin treatment was compared with the wild-type reporter. *, Significantly different fold induction in the treated cells vs. the control cells for each reporter; #, a significant difference in the level of luciferase expression from the control treated cells transfected with wild-type reporter.