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. 2008 Jun;10(6):997–1030. doi: 10.1089/ars.2007.1893

FIG. 8.

FIG. 8

Ferritin and iron storage. Ferritin is composed of 24 subunits, heavy (H) and light (L), with varied ratios of H to L in different cell types and physiologic conditions. Ferritin H has ferroxidase activity to convert Fe2+ to Fe3+ inside ferritin shell. Iron is imported and exported through the channels constructed by ferritin H or L subunits.