FIG. 8.

Cytokines detected in the lungs of vaccinated IFN-γ-KO and wild type animals. IFN-γ-KO and B6 mice were vaccinated with DNA (D) and vaccinia virus (V) in a prime-boost regimen. Inoculations were in the order D-D-V-D. One month after the last injection, vaccinated and unvaccinated mice were challenged with rSeV-env. Mice were given ip injections with the anti-CD8 2.43.1 mAb on days −5, −3, −1, +1, and +3 relative to rSeV-env challenge. BAL fluids from vaccinated and unvaccinated mice were examined for IL-2, IFN-γ, IL-4, and IL-5. Results are shown for individual mice.