Fig. 3.
Flecainide 1 μM increases mean open time, fo, and Po, of Kir2.1 channels. (A) Single-channel recordings under control conditions and after perfusion with flecainide. Closed- and open-channel levels are indicated by C and O, respectively. Unitary current amplitude (B), mean open time (C), fo (D), and Po (E) in the absence and presence of flecainide. (F) Po–V in control conditions and in the presence of flecainide. Solid lines represent the fit of a Boltzmann function to the data. (G) Single-channel current-voltage relationships in the absence and presence of flecainide. Solid lines represent the fit of a linear function to the data. Each point/bar represents the mean ± SEM of six experiments. *P < 0.05 and **P < 0.01 vs. control.