Fig. 2.

miRNA profiling of the hematopoietic hierarchy. (A) Hierarchical lineage relation of analyzed populations. The relation of 27 purified subpopulations representing all hematopoietic lineages is shown. These cell types include 12 myeloid populations (red), 7 lymphoid populations (green), and 8 progenitor and stem cell populations (blue). (B) Phylogenetic tree reconstructed from miRNA expression data. The grouping of cell populations based on miRNA expression profiling reveals a clear separation of myeloid, lymphoid, and stem cell/progenitor populations with four distinct subgroups present in the myeloid branch. Circles indicate the number of miRNA species detected in each population. Bootstrap values are indicated next to branch nodes.