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pH change of the aqueous contents of M2PLs in response to the induction of a 62 mV electrical potential, positive outside (A) or inside (B). The initial pH was symmetrical, and the [K+] gradient was induced at time = 0, with initial concentrations [K+]in = 0.13 M, [Na+]in = 0 M, [K+]out = 0.011 M, [Na+]out = 0.119 M (A) and [K+]in = 0.01 M, [Na+]in = 0.12 M, [K+]out = 0.12 M, [Na+]out = 0.01 M (B).
