Table 6. 10-year total mortality, cardiovascular mortality and major coronary event rates in men by Framingham Risk Category and Ankle Brachial Index at baseline for all studies combined in the ABI Collaboration.
| Ankle Brachial Index: | ≤ 0.90 | 0.91 to 1.10 | 1.11 to 1.40 | >1.40 | Overall |
|---|---|---|---|---|---|
| Total mortality % (95% CI) | |||||
| Framingham Risk Category1 | |||||
| 1. Lowest (n=5,746) | 27.1 (16.0 to 38.2) | 11.4 (5.9 to 16.8) | 8.3 (5.4 to 11.2) | 14.1 (4.2 to 24.0) | 10.4 (6.9 to 13.9) |
| 2. (n=4,319) | 37.3 (17.8 to 56.9) | 15.8 (10.6 to 21.0) | 11.3 (8.2 to 14.5) | 19.9 (7.5 to 32.4) | 13.8 (9.9 to 17.7) |
| 3. (n=3,544) | 37.6 (26.1 to 49.1) | 19.7 (13.6 to 25.9) | 14.2 (9.9 to 18.5) | 23.5 (9.5 to 37.6) | 17.6 (13.1 to 22.2) |
| 4. (n=5,814) | 38.1 (28.5 to 47.8) | 23.6 (16.9 to 30.4) | 19.2 (14.8 to 23.5) | 38.4 (12.3 to 64.6) | 23.1 (17.6 to 28.6) |
| 5. Highest (n=5,532) | 57.1 (45.4 to 68.9) | 36.4 (29.1 to 43.7) | 31.0 (25.2 to 36.7) | 43.6 (28.1 to 59.1) | 38.0 (30.9 to 45.0) |
| Overall (n=24,955) | 46.3 (36.1 to 56.6) | 23.0 (15.8 to 30.2) | 16.7 (12.4 to 21.0) | 29.2 (18.9 to 39.5) | |
| Cardiovascular mortality % (95% CI) | |||||
| 1. Lowest (n=5,746) | 4.6 (0.0 to 10.8) | 3.1 (0.0 to 6.5) | 1.3 (0.5 to 2.0) | 2.7 (0.0 to 6.8) | 1.6 (0.8 to 2.4) |
| 2. (n=4,319) | 17.5 (6.6 to 28.3) | 3.5 (1.5 to 5.5) | 1.5 (0.7 to 2.3) | 8.2 (0.0 to 18.8) | 2.3 (1.3 to 3.4) |
| 3. (n=3,544) | 11.5 (2.4 to 20.6) | 5.1 (3.1 to 7.2) | 3.6 (1.9 to 5.2) | 8.3 (0.3 to 16.2) | 4.4 (2.8 to 6.0) |
| 4. (n=5,814) | 14.2 (10.2 to 18.2) | 8.0 (5.2 to 10.8) | 4.8 (3.3 to 6.4) | 5.6 (0.0 to 12.2) | 7.3 (5.2 to 9.3) |
| 5. Highest (n=5,532) | 27.9 (20.7 to 35.1) | 12.5 (8.9 to 16.1) | 9.9 (6.8 to 13.1) | 10.7 (2.0 to 19.4) | 14.0 (10.6 to 17.4) |
| Overall (n=24,955) | 18.7 (13.3 to 24.1) | 7.3 (5.0 to 9.6) | 4.4 (3.2 to 5.7) | 6.9 (2.8 to 11.0) | |
| Major coronary events2 % (95% CI) | |||||
| 1. Lowest (n=5,643) | 5.8 (0.0 to 12.7) | 3.7 (1.4 to 6.0) | 3.4 (2.5 to 4.3) | 4.0 (1.1 to 6.8) | 3.5 (2.4 to 4.6) |
| 2. (n=4.151) | 20.0 (9.6 to 30.4) | 5.9 (3.6 to 8.1) | 6.8 (5.7 to 8.0) | 5.0 (0.7 to 9.3) | 7.1 (5.5 to 8.8) |
| 3. (n=3,241) | 20.2 (8.0 to 32.3) | 10.0 (6.2 to 13.8) | 8.7 (6.4 to 11.0) | 12.9 (0.0 to 27.8) | 10.1 (7.5 to 12.6) |
| 4. (n=4,179) | 27.5 (18.5 to 36.6) | 14.8 (9.9 to 19.7) | 12.6 (9.6 to 15.7) | 9.7 (0.0 to 19.7) | 15.3 (11.5 to 19.1) |
| 5. Highest (n=4,219) | 31.4 (21.9 to 40.8) | 20.0 (14.4 to 25.5) | 17.6 (12.2 to 23.0) | 12.0 (3.6 to 20.3) | 21.5 (16.7 to 26.3) |
| Overall (n=21,433) | 26.8 (19.5 to 34.1) | 12.9 (9.2 to 16.7) | 9.4 (7.4 to 11.4) | 7.2 (4.3 to 10.1) | |
1
Categories of predicted 10-year % incidence of coronary heart disease, including coronary death, myocardial infarction and angina, are based on whole number cutpoints for scores; category 1 = <10%, 2 = 10-14%, 3 = 15-19%, 4 = 20-29%, 5 = ≥ 30%
2
Excluding Health in Men, Hoorn and InCHIANTI studies.
Analysis based on random effects pooling of Kaplan-Meier estimates from the individual studies.