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. 2010 Sep 2;6(9):e1000912. doi: 10.1371/journal.pcbi.1000912

Figure 4. Definition of alternative Th subtypes based on the expression of the master regulators.

Figure 4

Each of the four master genes considered (TBET, GATA3, RORGT and FOXP3) is positively auto-regulated. The first five rows correspond to the canonical Th cell subtypes expressing no (Th0) or a single master regulator (Th1, Th17, Th2, Treg). The remaining rows correspond to hybrid Th cell subtypes that express more than one of the master regulators, i.e. that show hybrid patterns. Additional positive circuits (proliferation and STAT3-related) generate further subtypes. The circuit analysis predicts 48 stable patterns (4 for each of the 12 groups; each pattern corresponds to one cell of the table under the heading “Other circuits”). Only 28 of these patterns (greyed cells) are compatible with at least one of the input combinations considered here (cf. Figure 5). The values in the cells indicate how many input combinations are compatible with this stable state. Five patterns are not compatible with any input combination (cells with dashes).