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. 2010 Sep 2;6(9):e1000912. doi: 10.1371/journal.pcbi.1000912

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Naldi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The Th cell subtypes observed in silico are grouped into three main constellations (Th0, Th1 and Th2, delimited by different backgrounds). The different panels correspond to different environmental conditions listed in Figure 5: (a) no stimulation, (b) APC only, (c) pro-Th1, (d) pro-Th2, (e) pro-Treg, and (f) pro-Th17. Arrows between cell lineages denote switches elicited by the corresponding environment. Cell colouring denotes the activity of the master regulators: GATA3 (blue), T-bet (red), Foxp3 (green) and RORt (orange).

Inline graphic — The Th cell subtypes observed in silico are grouped into three main constellations (Th0, Th1 and Th2, delimited by different backgrounds). The different panels correspond to different environmental conditions listed in Figure 5: (a) no stimulation, (b) APC only, (c) pro-Th1, (d) pro-Th2, (e) pro-Treg, and (f) pro-Th17. Arrows between cell lineages denote switches elicited by the corresponding environment. Cell colouring denotes the activity of the master regulators: GATA3 (blue), T-bet (red), Foxp3 (green) and RORt (orange).