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. 2010 Sep 2;6(9):e1001087. doi: 10.1371/journal.pgen.1001087

Figure 5. Expression of Arctic Aβ42 peptides in the adult fly nervous system causes locomotor dysfunction.

Figure 5

Climbing ability of UAS-ArcAβ42/+;elavGS/+ and UAS-Aβ40/+;elavGS/+ flies on + and − RU486 SY medium was assessed at the indicated time-points (see Materials and Methods). Data are presented as the average performance index (PI) ± SEM and were compared using two-way ANOVA and Tukey's honestly significant difference (HSD) post-hoc analyses (number of independent tests (n) = 3, number of flies per group (nt) = 39–45). *P<0.05 comparing PI of UAS-ArcAβ42/+;elavGS/+ +RU486 flies to that of untreated and Aβ40 over-expressing controls at the indicated time points (Tukey's HSD).