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. Author manuscript; available in PMC: 2010 Sep 2.
Published in final edited form as: Mol Biosyst. 2010 Jun 28;6(8):1389–1402. doi: 10.1039/c003917a

Scheme 7.

Scheme 7

a) [Ph P-CHMeR5]+ 3 Br−, tBuOK / THF, 2–3 h, (b) H2, Pd/C, THF, rt, over night (R5 = H) or TsNH2NH2, THF, 100 °C, 3 h (R5 = Me), (c) LDA, THF, −78 °C, 1 h then DMF–THF, 78 °C, 1 h, yield: 47–53% for 3 steps, (d) MeMgBr, Et2O, 0 °C, 30 min, (e) MnO2, dioxane, 90 °C, 9 h, yield: 63–88% for 2 steps, (f) NH2NH2, DMF, 120 °C, 24 h, yield: 7–11%.