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. 2010 Sep 2;6(9):e1001085. doi: 10.1371/journal.ppat.1001085

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Cohen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. The sequence alignments obtained from the EMBOSS package: Needle global alignment analysis. I) TCRα CP / SIV gp41 TMD sequences alignment II) TCRα CP / HIV-1 gp41 TMD sequences alignments. B. Z-Score alignment histogram. TMD Entries scores were clustered according to taxonomic species division. The mean of each cluster was Z-normalized. The histogram describes the distribution of alignment scores over the 265 clusters dataset C. Wilcoxon Rank Test. The HIV-1 gp41 cluster (n = 47) was compared against all the other 264 clusters using Wilcoxon Rank Test. p-value results of comparisons are presented in a log scale. Significance of ranking was determined according to Benjamini-Hochberg method (E (FDR)<0.05). Clusters which are significantly lowered ranked over HIV-1 gp41 are marked (black dot) and presented left to the arrow. Cluster which were not significantly distinct in ranking from HIV-1 gp41 are marked (diamond).