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. 2010 Sep 2;6(9):e1001085. doi: 10.1371/journal.ppat.1001085

Figure 4. Gp41 TMD inhibit T-cell activation induced by mitogenic antibodies to CD3.

Figure 4

T-cells were activated with 1µg/ml anti-CD3 and APC in the presence of 50µg/ml gp41 TMD or TCRα CP and the proliferative responses were assayed. The uninhibited T-cell proliferative responses were 9103±208 cpm. The background proliferation in the absence of antigen was 257±41 cpm. The data are presented as normalized mean proliferation percentage (control, no peptide = 100%) + SD (n = 5 or more, ** p<0.01). There was no significant statistical difference between the TCRα CP and the control.