Table 3.
Univariate and multivariable regression and odds ratio for association of rs738409 genotype with histological parameters of disease severity in adults with NAFLD
| Predictor | Steatosis | Portal Inflammation | Lobular Inflammation | Mallory-Denk Bodies | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate p-value |
Multivariate p-valueb (FDR q– valueh) |
OR (95% CI)d | Univariate p-value |
Multivariate p-valueb (FDR q– value) |
OR (95% CI)e | Univariate p-value |
Multivariate p-valueb (FDR q– value) |
OR (95% CI)f | Univariate p-valueg |
Multivariate p-valueg (FDR q– value) |
OR (95% CI)g | |
| rs738409 | 0.005a | 0.012 (0.033) |
1.46 (1.07– 2.01) |
0.009a | 2.5×10−4 (0.017) |
1.57(1.24– 1.99) |
4×10−4a | 0.002 (0.025) | 1.84 (1.33– 2.55) |
0.058 | 0.015 (0.042) | 1.6 (1.46– 3.07) |
| Age | 1.1×10−5b | 5.5×10−5 | 0.98 (0.97– 0.99) |
4.5×10−7b | 8.1×10−6 | 1.03 (1.02– 1.05) |
0.998b | 0.098 | 0.99 (0.98– 1.01) |
1.3×10−9 | 1.4×10−4 | 1.03 (1.01– 1.05) |
| Female Gender |
0.564c | 0.075 | 1.20 (0.89– 1.62) |
0.008c | 0.754 | 1.01 (0.69– 1.48) |
0.001c | 4.8×10−5 | 1.60 (1.18– 2.17) |
1.7×10−8 | 7.3×10−5 | 2.12 (1.46– 3.07) |
| BMI | 0.756b | 0.937 | 0.99 (0.97– 1.01) |
5×10−5b | 4×10−5 | 1.04 (1.01– 1.06) |
0.103b | 0.020 | 0.98 (0.96– 1.00) |
0.382 | 0.952 | 1.00 (0.98– 1.03) |
| Diabetes Type 2 |
0.075c | 0.266 | 0.83 (0.60– 1.13) |
9.7×10−5c | 0.010 | 1.72 (1.19– 2.48) |
0.649c | 0.795 | 0.97 (0.70– 1.33) |
7.2×10−7 | 1.5×10−4 | 1.95 (1.38– 2.75) |
| Alcohol Consumption |
0.171a | 0.043 | 0.91 (0.44– 1.87) |
6.9×10−5a | 0.088 | 0.53 (0.18– 1.55) |
0.694a | 0.336 | 1.52 (0.73– 3.18) |
1.8×10−4 | 0.06 | 1.380 (0.606– 3.143) |
Jonkheere-Terpestra test
Ordinal regression
Mann-Whitney U
Multivariable binary logistic regression for steatosis ≥ 33% vs. < 33%. rs738409 entered using dominant model (i.e. genotype CG or GG vs. CC)
Multivartiable binary logistic regression for more than mild portal inflammation vs. none or mild. rs738409 entered using additive model
Multivariable binary logistic regression for lobular inflammation ≥ 2 foci vs. < 2. rs738409 entered using dominant model
Multivariable binary logistic regression. rs738409 entered using dominant model
False discovery rate evaluated for association with SNP only. q<0.05 is significant.