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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Clin Cancer Res. 2010 Jul 9;16(17):4311–4312. doi: 10.1158/1078-0432.CCR-10-1496

Figure 1.

Figure 1

Targeting of signaling pathways by arsenic trioxide in chronic lymphocytic leukemia cells. Activation of the JNK MAPK pathway is required for induction of apoptosis of CLL cells. Arsenic trioxide treatment of leukemic cells also results in inhibition of the PI 3’K/AKT pathway; and pharmacological targeting of this pathway enhance the antileukemic effects of arsenic trioxide. The potential involvement of other MAPK pathways, such as the p38 MAPK and MEK/ERK pathways which play important roles in control of growth and survival of other types of leukemic cells, in the regulation ATO-dependent responses in CLL cells remains to be defined.