. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: J Infect Dis. 2010 Oct 1;202(7):1114–1125. doi: 10.1086/656147

Table 2.

Antibody Responses for the HIV-Infected PCV and PPV Arms

	At Least 2 of 4 Serotypes		At least 3 of 4 Serotypes		Serotype 4		Serotype 9V		Serotype 14		Serotype 19F
	N (%) With a Positive Immune Response¹
Day	PCV	PPV	PCV	PPV	PCV	PPV	PCV PPV		PCV PPV		PCV PPV
14	67 (54)	23 (35)	37 (30)	11 (17)	54 (43)	17 (26)	68 (54)	22 (33)	57 (46)	27 (41)	37 (30)	12 (18)
60	68 (57)	23 (36)	37 (31)	9 (14)	48 (40)	15 (23)	63 (53)	25 (39)	61 (51)	28 (44)	42 (35)	12 (19)
180	47 (41)	20 (31)	26 (22)	11 (17)	37 (32)	16 (25)	49 (42)	24 (38)	47 (41)	22 (34)	38 (33)	13 (20)
	Adjusted Odds Ratios for a Positive Immune Response (PCV to PPV) With 95% Confidence Intervals and P-values
Day	OR (95% CI) p-value		OR (95% CI) p-value		OR (95% CI) p-value		OR (95% CI) p-value		OR (95% CI) p-value		OR (95% CI) p-value
14	2.4 (1.2, 4.6) 0.009		2.2 (1.0, 4.9) 0.05		2.4 (1.2, 4.7) 0.01		2.5 (1.3, 4.8) 0.007		1.3 (0.7, 2.5) 0.39		1.9 (0.9, 4.1) 0.09
60	2.6 (1.4, 5.0) 0.004		2.6 (1.1, 6.0) 0.02		2.3 (1.1, 4.7) 0.02		1.7 (0.9, 3.1) 0.12		1.5 (0.8, 3.0) 0.19		3.5 (1.5, 7.9) 0.004
180	1.4 (0.7, 2.7) 0.34		1.3 (0.6, 2.9) 0.55		1.4 (0.7, 2.8) 0.36		1.1 (0.6, 2.1) 0.80		1.3 (0.7, 2.6) 0.39		1.8 (0.9, 3.8) 0.12
					Adjusted Differences (PCV-PPV) for Change from Baseline in IgG Concentration (log₁₀ ng/mL) With 95% Confidence Intervals and P-values
Day					Difference (CI) p-value		Difference (CI) p-value		Difference (CI) p-value		Difference (CI) p-value
14					0.31 (0.15, 0.48) <0.001		0.19 (0.03, 0.35) 0.02		0.07 (−0.11, 0.25) 0.43		0.10 (−0.06, 0.26) 0.23
60					0.21 (0.04, 0.38) 0.02		0.17 (0.01, 0.32) 0.04		0.14 (−0.05, 0.34) 0.14		0.19 (0.03, 0.34) 0.02
180					0.14 (−0.01, 0.29) 0.07		0.05 (−0.11, 0.21) 0.55		0.11 (−0.07, 0.28) 0.23		0.13 (−0.01, 0.28) 0.08

Primary endpoint: positive immune response to at least 2 of 4 serotypes at day 60