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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Jul 24;49(4):543–553. doi: 10.1016/j.yjmcc.2010.07.012

Figure 8.

Figure 8

Late potentials due to the delayed second upstroke of the epicardial response or to concelaed phase 2 reentry generated in a canine right ventricular wedge model of Brugada sydnrome. A: Control. B: BrS phenotype develops following exposure to the INa and ICa inhibitor terfenadine (5 uM); a late potential is registered in the the epicardial electrogram following an 80 ms delay coincident with the upstroke of phase 2 of the action potential (arrow). C: Further exposure to terfenadine leads to loss of the action potnatil dome at some epicardial sites (Epi 1) but not others leading to the development of a concealed phase 2 reentry which regsiters in the epicardial electrogram as a late pottnial with a 148 ms delay (arrow). Modified form [82], with permission.