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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Hepatology. 2010 Sep;52(3):987–998. doi: 10.1002/hep.23783

Figure 5. Stimulation of PBC macrophages in the presence of AMA and HIBEC apoptotic bodies is mediated by the Fc Receptor and is a consequence of M1 polarization.

Figure 5

(A) Comparison of cytokine secretion from MDMΦ from patients with PBC (n=8) cultured with HIBEC apoptotic bodies in the presence of AMA with (white bars) or without (black bars) pre-treatment with CD16 monoclonal antibody (clone 3G8). Cytokine levels were markedly decreased when FcγR was blocked (***p< 0.001). (B) Comparison of TNFα secretion from MDMΦ from patients with PBC (n = 8) and healthy controls (n = 8) after M1 polarization (HC M1), and untreated (HC) cultured with HIBEC apoptotic bodies in the presence of AMA. (***p< 0.001, *p<0.05).