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. Author manuscript; available in PMC: 2011 Sep 1.

Published in final edited form as: Aliment Pharmacol Ther. 2010 Sep;32(5):681–688. doi: 10.1111/j.1365-2036.2010.04391.x

Table 2.

Effects of Clonidine on Anorectal Sensorimotor Functions

	Before clonidine	During clonidine
Anal resting pressure	41 ± 3	41 ± 2
Anal squeeze pressure	71 ± 7	74 ± 6
Maximum tolerated pressure during compliance curve (mmHg)	37 ± 2	42 ± 1^†
Rectal capacity (mL)	245 ± 64	256 ± 51
Rectal compliance (Pr_half)	16.7 ± 1.4	18.4 ± 2.5
Rectal sensation
Threshold for desire to defecate
Pressure	16.7 ± 2.0	16.7 ± 2.3
Volume (mL)	111 ± 17	113 ± 23
Threshold for urgency
Pressure	23.4 ± 2.2	24.4 ± 2.9
Volume (mL)	169 ± 16.5	167 ± 23.1
VAS Score (urgency, 8 mm^*)	30 ± 7.5	30 ± 8.4
VAS Score (urgency, 16 mm^*)	46 ± 7.3	44 ± 8.4
VAS Score (urgency, 24 mm^*)	62 ± 5.9	66 ± 7.9

Values are Mean ± SEM in mmHg except where stated

^*

Distending pressure = Operating pressure + specified pressure

^†

p = 0.027 vs pre clonidine