Table 3.

Haplotype Trend Regression Analyses of single nucleotide polymorphisms (SNP) in IL-10R1.

Gene, haplotypes	European Americans					African Americans
	Haplotype Frequency (%)		P		OR (95% CI)	Haplotype Frequency (%)		P		OR(95% CI)
	Cases (n=200)	Controls (n=550)	Global	Haplotype		Cases (n=110)	Controls (n=424)	Global	Haplotype
IL-10R1			0.02					0.08
AACAGGC	49.3	51.2		0.94	0.98 (0.58–1.65)	60.4	68.9		0.05	0.51 (0.25–1.00)
AACAAGC	3.6	1.9		0.12	4.19 (0.69–25.49)	0.9	0.4		0.85	1.45 (0.03–63.85)
AACAGAC	13.3	13.9		0.87	1.07 (0.49–2.32)	18.9	15.7		0.20	1.77 (0.74–4.25)
AACAGGT	1.7	4.1		0.04	0.14 (0.02–0.94)	2.2	0.4		0.25	7.82 (0.24–260)
AATAGGC	8.6	10.1		0.35	0.67 (0.28–1.56)	12.1	10.2		0.55	1.35 (0.50–3.63)
AGCAGGC	5.7	3.5		0.03	6.21 (1.22–31.54)	0.9	1.6		0.36	0.22 (0.01–5.78)
GACAGAC	12.1	9.2		0.12	1.96 (0.84–4.56)	2.2	2.0		0.70	1.65 (0.13–20.42)
GACGGAC	2.7	3.6		0.40	0.51 (0.11–2.45)	1.8	0.6		0.27	6.72 (0.23–193)

Haplotypes were estimated using the ordered SNPs: rs3135932, rs2228055, rs4252279, rs4252314, rs4252286, rs2229113, rs2229114.

Regression models are adjusted for square root of nadir CD4+ T-cell count, log₁₀HIV-1 load, age, gender and HAART.