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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Cancer Res. 2010 Jul 19;70(17):6704–6714. doi: 10.1158/0008-5472.CAN-10-0460

Figure 2.

Figure 2

The effect of MEK inhibition on IGFR network dynamics. (A) Protein profiles of IGF-1-stimulated MDA-MB231 cells predicted by the trained mass-action model. Solid red lines represent the protein time courses of the noninhibited cells, and solid green lines represent the protein profiles of MEK-inhibited cells. (B) Protein phosphorylation in MDA-MB231 cell lysates after stimulation with 75 ng/mL IGF-1 detected in triplicate by RPPA. Solid circles and red lines represent the protein time courses of noninhibited cells, and solid circles and green lines represent the protein profiles of cells inhibited with MEK inhibitor for 4 hours.