Table 4.
Model 1 Death (any cause) or Liver Transplantation | Model 2 Any liver-related outcome | Model 3 Decompensated liver disease | Model 4 HCC | Model 5 Liver-related death or Liver Transplantation | ||||||
---|---|---|---|---|---|---|---|---|---|---|
N=526 (72 events) | N=526 (91 events) | N=526 (50 events) | N=526 (35 events) | N=526 (55 events) | ||||||
Variables | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI |
Age (per 1 year) | 1.05 | 1.01–1.10* | ||||||||
Baseline Platelets (per 10,000/mm3) | 0.88 | 0.83–0.92* | 0.85 | 0.81–0.89* | 0.86 | 0.80–0.92* | 0.85 | 0.79–0.92* | 0.86 | 0.81–0.92* |
Baseline albumin (per 0.1 g/dL) | 0.89 | 0.83–0.94* | 0.91 | 0.87–0.96* | 0.90 | 0.83–0.96* | 0.88 | 0.83–0.95* | ||
Baseline alk phos (per 10 U/L) | 1.08 | 1.02–1.13* | ||||||||
Baseline AFP (per 10 ng/ml) | 1.06 | 1.01–1.12* | ||||||||
Treatment Response | ||||||||||
BT/R vs. NR | 0.29 | 0.10–0.79* | 0.46 | 0.22–0.96* | 0.57 | 0.22–1.46 | 0.96 | 0.36–2.54 | 0.43 | 0.15–1.21 |
SVR vs. NR | 0.17 | 0.06–0.46* | 0.15 | 0.06–0.38* | 0.13 | 0.03–0.53* | 0.19 | 0.04–0.80* | 0.12 | 0.03–0.48* |
The following variables were not significant in any model: race, stratum (fibrosis vs. cirrhosis), and AST/ALT ratio