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. Author manuscript; available in PMC: 2011 Aug 12.
Published in final edited form as: J Med Chem. 2010 Aug 12;53(15):5770–5781. doi: 10.1021/jm100582w

Figure 3.

Figure 3

Characterization of NAAA inhibition by compound 7h in vitro. (A) Concentration-response curves for inhibition of NAAA by 7g (meta-biphenyl derivative, closed triangles) and 7h (para-biphenyl derivative, closed squares). (B) Preincubation time-course of 7h. (C) Michaelis-Menten analysis of 7h (vehicle – closed squares; 100 nM 7h: closed upright triangles; 200 nM 7h: closed inverted triangles). (D) Overnight dialysis of 7h (pre-dialysis: filled bars; post-dialysis: shaded bars). *** P < 0.001 vs vehicle-preincubation (n = 3–5).