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. Author manuscript; available in PMC: 2011 Aug 12.
Published in final edited form as: J Med Chem. 2010 Aug 12;53(15):5770–5781. doi: 10.1021/jm100582w

Table 1.

Inhibitory Potencies (IC50) of Tested Compounds 1,7a-d,8a,10,11a,12,15,20a,b23, on rat NAAA Activity.

Cpds. Structure IC50 (nM) ± S.E.M.
1 graphic file with name nihms220270t1.jpg 2,960 ± 30023
7a graphic file with name nihms220270t2.jpg 420 ± 2023
8a graphic file with name nihms220270t3.jpg 6,000 ± 60023
10 graphic file with name nihms220270t4.jpg >100,000
11a graphic file with name nihms220270t5.jpg >100,000
12 graphic file with name nihms220270t6.jpg >100,00023
15 graphic file with name nihms220270t7.jpg >100,00023
20a graphic file with name nihms220270t8.jpg >100,000
20b graphic file with name nihms220270t9.jpg 3,200 ± 400
23 graphic file with name nihms220270t10.jpg 11,000 ± 2,200
7b graphic file with name nihms220270t11.jpg 1,850 ± 200
7c graphic file with name nihms220270t12.jpg 1,500 ± 100
7d graphic file with name nihms220270t13.jpg 460 ± 100